Introduction: A food which is considered as a taboo is a food that is strictly forbidden in the community, for health, cultural or spiritual reasons. Food taboos are known from all human societies and may be found in different forms all over the world. Pregnancy is viewed as a critical period in the life of women and is usually subjected to a number of food taboos as a way of keeping their lives and that of the unborn baby. Objective: To determine food taboos practices and associated factors among pregnant Women in Mandura woreda, Metekel zone, Northwest Ethiopia. Method: An institution based quantitative and qualitative cross-sectional study design was employed. Systematic sampling technique was used to select 422 pregnant women, who was attending Antenatal Care service from public health facilities of Mandura woreda. The questionnaires was checked for completeness, cleaned manually and entered in to EPI info 7 and exported to SPSS version 20.0 for further analysis. Both bivariate and multivariate logistic-regressions analyses were used to identify associated factors. Result: The overall response rate was 100% of the total 422 pregnant mothers, 55.2% of them encounter food taboos at least for one food item. Age between 15-24 years (AOR,2.953,95%CI,1.364-6.396),25-34 years (AOR,2.515,95%CI,1.367-4.672),eating twice per a day (AOR,2.210,95%CI,1.733-5.945),changing feeding habit during pregnancy (AOR,2.541,95%CI,1.545-4.178), previous history of ANC utilization (AOR,2.708,95%CI,1.592 4.603), were significantly associated with food taboo. Conclusions and Recommendation: Prevalence of food taboo among pregnant women was mother than half in study area. Age of pregnant women, average monthly income, family size, changing feeding habits during pregnancy and meal frequency were found to be factors affecting food taboo. Most participants in FGD agreed that food taboos existed among pregnant women in the community. Improved nutritional counselling program in providing effective nutrition counselling is highly recommended for reproductive age of pregnant women. It should be underline the importance of education in general; changing food habits through giving health education about nutrition, improving maternal family size through strengthening family planning methods during ANC follow up.