This study is aimed at exploring the effect of work life conflict on employee’s job performance in North West Region Ethio-telecom. To achieve this purpose, Explanatory study was used to analyze the data collected through cross-sectional survey questionnaire from a sample of 245 North West Region Ethio-telecom permanent employees. These respondents were selected using proportional stratified random sampling method from shops and region office. The data collected through questionnaire were analyzed using Statistical measures such as correlation and multiple regression analysis. The major findings of the study revealed that, the three work life conflict dimensions such as work to personal life interference, personal life to work interference, and work overload and employee job performance found to be inversely and significantly related with employees employee’s job performance. The three work life conflict dimensions of this research significantly explain the variations in employee’s job performance. Work to personal life interference, work overload and personal life to work interference statistically and negatively predict the variation in job satisfaction. Based on the findings of the study, it is recommended that Top management should realize the effect of work life conflict on employee’s job performance and should implement work life balance programs, practices, and policies.