Abstract Understanding the determinants of operational excellence is critical to grasp great results at the end. The purpose of this research is to see the main factors which affect the successful implementation of operational excellence. Based on different literature reviews, this paper proposed three main factors as determinants for operational excellence. These are Leadership, HR practice and Organization culture. This done by collecting relevant data from East Africa Bottling share company Bahir Dar plant employees. The data collection tool used for this research development was questionnaire. The data collection was done by taking 210 samples from the total population of 423 with successful response rate of 84.3%. The sampling technique followed was simple random probability sampling method. The collected data analyzed by using descriptive and inferential statistics. SPSS version 26 software used as a supporting tool for conducting data analysis using statistical techniques. The research found that leadership, HR practice and Organizational culture positively correlate and significantly determine successful implementation of operational excellence. The researcher recommended the organization to keep its norms, values and behavior to maintain the current organizational culture and the management need to review on enhancing trust relations, empowering employees and compensation package. Since the contribution of leadership, HRM practice and Organizational culture have 62% on operational excellence the researcher recommended further research to understand additional determinants of operational excellence.