Background: Iron and folic acid supplementation is the feasible and cost effective strategy to control and prevent anemia in pregnancy. In Ethiopia, the national data suggests that from all pregnant women supplemented with these tablets only 0.4% consumed more than 90 tablets during their pregnancy time. The factors for this low adherence are not clearly known. Objectives: The main objective of this study was to determine status of iron folate adherence and the associated factors among pregnant mothers attending antenatal care at public health facilities in Bahir Dar town, Northwest Ethiopia, 2017. Method: A facility based cross sectional study was conducted among pregnant mothers attending antenatal care in Bahir Dar town. The study was conducted among 395 selected using systematic random sampling. A pre-tested structured questionnaire was used to collect the data. The collected data were entered to Epi info version 3.5.1 and were analyzed using SPSS version 20 statistical software. Independent variables with P-value less than 0.20 in the bivariate analysis were included in the multivariable logistic regression model to control confounders associated with the dependent variable. Results: The results of this study showed that about 60% of pregnant mothers attending antenatal care had iron folate adherence. Adherence to iron folate supplements was significantly higher among mothers whose educational status was secondary and above (AOR=5.6 95% C.I: (2.9, 10.5), had family support (AOR=3.6, 95% C.I: (2.2, 6.1) and health care provider gives medical advice (AOR=2.8, 95% CI (1.5, 4.9) to take iron folate daily have adherence to the supplements. On the other hand, pregnant mothers who had experienced side effects while they took iron folate supplements were less likely to have adherence to the supplements. Conclusion Adherence to IFA supplement utilization is low in the study area. Mothers educational status, Family support and health care provider give medical advice about IFAS has positively associated with iron/folate Adherence on the other hand experienced side effects were Negatively associated with adherence to IFA supplement. Presence of side effects were identified as major reasons for skipping a dose; while nausea and vomiting and epigastria pain and nausea upset were the most frequently responded side effects