Introduction: Hypertension is a major public health problem worldwide. Knowledge and skill on hypertension-related nutrition and life style modifications play an important role in controlling of hypertension and in preventing its long-term complications on hypertensive patients. However, the level of knowledge and practice of hypertensive patients towards nutritional as well as lifestyle factors was not clearly identified and understood in the study area which justifies to did this research. Objective: To assess knowledge and practice of hypertensive patients towards nutritional and lifestyle related factors of blood pressure control in Felege Hiwot Referral Hospital, Bahir Dar, North West Ethiopia. Methods: An institution based cross sectional study was conducted from November 1, to December 31, 2016 among 339 hypertensive patients using systematic and simple random sampling technique. The data was collected by interviewer administered structured questionnaire and was analyzed by using SPSS version 20.0. Binary logistic regression model and multivariate regression was used to test association between dependent and independent variables.