Introduction: Malnutrition contributes to more than half of all child deaths in Ethiopia, and 38 % of the country‟s children are stunted. Focusing on infant and young child feeding (IYCF) practices, such as exclusive breastfeeding from birth to 6 months and appropriate complementary feeding for children 6–23 months of age, is critical to prevent stunting and nutrition-related morbidity and mortality. In this respect, animal source foods such as meat, milk, and eggs are deemed desirable as they offer nutrient dense and an excellent source of vitamins and minerals such as iron and zinc. Objective: The main objective of this study was to assess animal source food consumption practice and associated factors among mothers of children age 6-23 months in South Achefer district, Northwest Ethiopia. Methods: A community based cross sectional study design was conducted from July 1- 30/ 2010 E.C. A multi-stage random sampling technique was used to sample 475 mothers who had children aged 6–23 months. Data on animal source food feeding practice were collected by using a structured and pretested questionnaire, cleaned and entered into Epi info 7 and analyzed using SPSS 23 software. Both bivariate and multivariate logistic regression analysis were used to analyze the data. Odds ratio along with 95% CI was estimated to identify factors associated with Animal source food consumption. Level of statistical significance was declared at p value < 0.05 Results: In this study, results revealed that the consumption of animal source food among children aged 6-23 months in the study area was low. Only 17 % of the children were reported to have consumed foods either flesh or egg as animal source of foods 24-hours preceding the survey. Intake of Animal source food by children ages ranged 12 -17 months (AOR=3.84; 95% CI=1.73, 8.49) and 18- 23 months (AOR=7.2; 95% CI=3.21, 16.16) were found to be 3.84 and 7.2 higher compared to children within the youngest age category (6-11months) respectively. Animal source food feeding practice was also significantly associated among mothers who had attained primary and secondary level of education as compared to those who had no formal education. Likewise, live stockownership was 3.41 more likely experienced feeding of animal source of food than who have no live stocks. Conclusion: In this study, consumption of animal source of foods (especially flesh or egg) between 6-23 months of age was very low. Stunting may be continued as predominant problem in Amhara region. Age of the child, educational status of the mother and livestock ownership were associated with consumption of animal source of food. Recommendations: Special attention should be given by the family in providing food from animal sources to children aged 6 - 11 months and Sustained nutrition education to mothers regarding proper Animal source food feeding practices in collaboration with the respective stockholder is highly recommended. Governmental or non-governmental organization working on the nutritional program should strength their behavioral change communications in this district.