Plyometric training were important to improve physical fitness components. The main objective of this study was to examine the effect plyometric training on selected physical fitness variables of male students football skill on secondary schools in kamashi woreda. To achieve the purpose, Quasi-Experimental design was used. 40 male football players of Kamashi and Engginer Tigire were taken simple random sampling as a sample study their age were 16-18 years. Experimental group (n=20) performed plyometric training two days per week for 3-month on squat jump, Bounding speed and Illinois agility drill and control group (n=20) however, did not perform this plyometric training, both groups undergone normal football training program. And both groups had taken pre and post-tests. So, all subjects participated in 3 selected football skill performance tests: slalom 30m dribbling, speed dribbling & power shoot. The data was analyzed and compared with the help of statistical procedures in which arithmetic mean, standard deviation and paired t- test was used. The level of p≤0.05 considered as significant level. The result showed that on slalom 30m dribbling test control group MD=-140 & P=.078 while experimental MD=1.01 & P=.000, speed dribbling test control MD=-0.124 & P=.065& whereas experimental MD=0.1375 & P=.002 and power shooting test control group MD=.040 & P=.874 while experimental MD=-0.90& P=.004.Therefor, plyometric training for twelve weeks is more effective in increasing the dribbling and shooting skills of male football players of students in Kamashi Woreda secondary school. Generally, the present study concluded that plyometric training had a significant effect on students’ football skill performance through the selected football skill tests. Hence, plyometric training is effective and beneficial for the enhancement of male students’ football skill performance. Keywords: plyometric, Power, agility, Speed, Eccentric, concentric and Amortization.