Low soil fertility status due to erosion, intensive farming and leaching are the major problems limiting current maize and tef yield. Field experiments were conducted at Yilmana Desnsa District, Northwestern Ethiopia in 2016/2017 with the objective of assessing nutrient status of the soil; evaluate the chemical quality of compost; quantify the effects of integrated fertility management on yield and yield components of maize and tef; and evaluate changes in soil physico-chemical properties due to integrated nutrient management in the study area. Maize variety named BH- 540 and tef variety called Kuncho were used as test crops. The treatments were factorial combinations of three compost rates (0, 5 and 10 t ha-1) and three mineral fertilizer rates (0, ½ and full recommended NPSBZn plus urea).NPSBZn fertilizer was added at the beginning of sowing while urea was added in split application method half at planting and half at knee-height stage. The treatments were laid out in RCBD design with three replications. SAS (12.00 version) software was used for analysis of diverse parameters. Soil samples were taken and analyzed before planting and compared with critical levels from literature to determine nutrient requirement for study area. Compost samples from pit and heap piles were also collected and analyzed to evaluate their quality. Soil samples were also collected from the experimental fields after harvest (0-20cm depth) to evaluate the effect of compost and mineral fertilizers on some soil physico-chemical properties. Soils were moderately acidic in pH and low in OM, N, P, S, B and Zn. However, the soils had sufficient amount of K, Ca and Mg. The analysis of 18 compost samples collected from farmers' backyards indicated that the composts were suitable and well matured for application to the field. Results from the maize and tef field experiments revealed that combined application of compost and NPSBZn mineral fertilizers improved yield and yield components of maize and tef. The highest maize and tef grain yield was obtained from the application of 10 tons ha-1 compost and full recommended mineral fertilizer rate (150 kg ha-1 NPSBZn + 200 kg ha-1 urea). Similarly, application of 10 t ha-1 compost and full of the recommended mineral fertilizer rate (150 kg ha-1 NPSBZn and 200 kg ha-1 urea) was found to be economical feasible for maize and tef. Analysis of soil samples after harvest demonstrated that application of sole compost, sole mineral fertilizer as well as their combinations affected soil chemical properties. To get maximum economic benefit farmers should integrate 10 t ha-1 compost and full of the recommended mineral fertilizer.