Abstract Background:BW, BMI,GA and MW is perhaps the most important indicator for infant survival as well as their physical growth and mental development.The main objective of this research was identify the determinants of BW, BMI,GA and MW simultaneously based on EDHS 2016. Methods:Cross sectional study design was used from Ethiopia demographic health survey 2016. Multivariate linear regression model was used to identify factors of BW, BMI,GA and MW simultaneously which had small standard errors as compare to separate model.Principal components analysis used to reduce response variables where as the determine number of common factors used to factor analysis. Results: The three principal components of BW, BMI,GA and MW with proportion of total population variance of principal components account for 98% and The most variation explain by BW,MW and BMI for PCA 1 ,PCA 2 and PCA variation determined by BW and GA response variables. Therefore,the mean of rst principal components of BW, BMI,GA and MW were statistically associated with number of tetanus injections before pregnancy,region,frequency of watching television,family size ,desire for more children for birth ,preferred waiting time for birth and husband educational level. In addition the mean of second principal components of BW, BMI,GA and MW were statistically associated with size of child,number of tetanus injections before pregnancy,region and desire for more children for birth.Moreover, the mean of third principal components of BW, BMI,GA and MW were statistically associated with size of child,preferred waiting time for birth, maternal age group and region.we extract two latent factors from four response variables. Conclusion: From our nding we conclude that maternal number of tetanus injections before pregnancy, region, frequency of watching television, family size, husband educational level, preferred waiting time for birth, desire for more children,age group and size of child were signi cant predictors of principal components of BW, BMI,GA and MW simultaneously at 5% level of signi cance.Further more,the two common extract factor also signi cant predictors for three PCA.Hence,innervation should be given to the pregnant during antenatal care for minimizing the risk of LBW,SGA,under weight and BMI of mothers. Keywords: BMI, BW, MW, GA, Separate Model, Multivariate Model, PCA, FA and EDHS. 3