“SYNTHESIS AND BIOLOGICAL ACTIVITIES INVESTIGATION OF CU (II) COMPLEXES WITH 2, 2`-BIPYRIDINE AND ADENINE AS LIGANDS”

FIKADU, TEGAFAW

dc.contributor.author	FIKADU, TEGAFAW
dc.date.accessioned	2018-11-06T10:27:50Z
dc.date.available	2018-11-06T10:27:50Z
dc.date.issued	2018-11-06
dc.identifier.uri	http://hdl.handle.net/123456789/9128
dc.description.abstract	Synthesizing new biologically active compounds sets up the efforts made in overcoming the alarming problem of microbial resistance to antibiotics. In line with this, a copper (II) coordination compound of 2, 2`-bipyridine and adenine were synthesized by the reaction between a cooper (II) salt and ligands in molar ratio (1:2:1) ,where M=Cu and the ligands are 2, 2`-bipyridine and adenine. The compound was characterized by using halide test, conductance measurement, solubility test, melting point and spectroscopic analyses (ICP-OES, FTIR, and Uv-Vis). Square pyramidal geometry with formula [Cu (bip)2(Ad)]Cl2.2H2O is proposed. The spectroscopic data suggests that the ligands are coordinated with the metal ion via nitrogen donor centers. The complex was tested for antibacterial activity against two Gram positive Staphylococcus aureus and Streptococcus pyogenes and two Gram negative Escherichia coli and Klebsiella pneumonia bacteria. The complex is found to be active against all the tested bacteria even against the Gram negative bacteria (Escherichia coli, Klebsiella pneumonia) the complex showed lower activity than the reference antibiotic drug(Gentamycin). Key words: Cu (II) chloride salts, copper (II) complex, antimicrobial activity, 2, 2`-Bipyridine, Adenine.	en_US
dc.language.iso	en	en_US
dc.subject	CHEMISTRY	en_US
dc.title	“SYNTHESIS AND BIOLOGICAL ACTIVITIES INVESTIGATION OF CU (II) COMPLEXES WITH 2, 2`-BIPYRIDINE AND ADENINE AS LIGANDS”	en_US
dc.type	Thesis	en_US