Corruption is one of the burning issue and impediments for democratization, good governance and sustainable development in Ethiopia. The Ethiopian government is aware of the severances of consequences of corruption and regarded it as a compulsive necessity to combat it. In response to this the FEACC emerged as a national anticorruption authority for the struggle to create a corruption-free society. This also leads to the establishment of the EACCs in the respective member regional states of the Ethiopian federation. Over the years however, the fight against corruption seems not to have achieved the desirable results. Accordingly, the purpose of this study was to investigate the role of Ethics and Anti-Corruption Commissions in combating corruption in the Amhara National Regional State. Specially, the study intended to; assesse the effectiveness of the ANRSEACC, identifies its challenges as well as investigate the strategies the Commission has used to address the challenges. To achieve the intended objectives, this study employed qualitative case study design based on primary and secondary data sources. Interviewees, document analysis and focused group discussion have employed through purposive and available sampling techniques. The data collected are analyzed using thematic analysis. The findings of the study revealed that, the role of ANRSEACC were found to be ineffective. Subsequently, resource constraint (financial, human and technical), limited spatial institutionalization, low public awareness and lack of public trust, problem of cooperation, lack of political commitment among government officials, problems related to whistleblowers and witnesses and operational inefficiency have been identified as major challenges. Whereas, operating alternative mechanisms, working in partnership with the stakeholders, applying comprehensive anticorruption strategies (education, prevention, and investigation) and working on identified focus areas were investigated as main strategies the Commission has used to address its challenges. Based on the findings, the major recommendation is to strengthen the strategies on the basis of identified problems, researches, consistent and coherent manners, broad based approaches and long term perspective to address its challenges and to play effective role in its anti-corruption struggle.