VOLTAMMETRIC DETERMINATION OF TINIDAZOL -- -  •  •  IN PHARMACEUTICAL TABLETS USING CARBON PASTE ELECTRODE

ABEBE, TAYE

dc.contributor.author	ABEBE, TAYE
dc.date.accessioned	2018-06-22T08:46:46Z
dc.date.available	2018-06-22T08:46:46Z
dc.date.issued	2018-06-20
dc.identifier.uri	http://hdl.handle.net/123456789/8723
dc.description.abstract	~ Differemiat pulse voltammetric method using carbon paste electrode was developed for the "cietermination of tinidazole in pharmaceutical tablets. Cyclic voltammetric investigation of tinidozole ,al a carbon paste electrode in the potential rangt? 0 to -700 mV showed an irreversible reduction .<d. tinidazole. After the optimization of' solution and method parameters, a linear dependence of peak c~rrent on the concentration of tinidazole was observed in the concentration range ofS x UT6-2 x 10;.._ Furthermore, a detection limit (LODj o/5:058 «ur' ;\1 and limit of quantiftcauon (LOQ) of i.'686 x I o·6 M were colculated. The developed method was usedfor the determination of tinidazo!e in pharmaceutical table! samples of three brads. 111e method was also used recove1y studies of spiked tinidazole in pharmaceutical tablet samples. Recoveries in the ranse o/75.89-95.44% indicated the potential applicability of the developed method for the determination of tinidazole in real sampler . • Abstract Key words: Tinidazole. differential pulse voltammetry, carbon paste electrode. Brit/on Robinson buffer solution. pharmaceutical tablets. ix	en_US
dc.language.iso	en_US	en_US
dc.subject	chemistry	en_US
dc.title	VOLTAMMETRIC DETERMINATION OF TINIDAZOL -- - • • IN PHARMACEUTICAL TABLETS USING CARBON PASTE ELECTRODE	en_US
dc.type	Thesis	en_US