Synthesis and Assessment of Antibacterial Activities of  a New Complexes of Ni (II) Containing 2, 2- Bipyridine, and 1,10-phenanthroline

Tewolign, Mitku

dc.contributor.author	Tewolign, Mitku
dc.date.accessioned	2017-10-13T05:09:51Z
dc.date.available	2017-10-13T05:09:51Z
dc.date.issued	2017-10-13
dc.identifier.uri	http://hdl.handle.net/123456789/7971
dc.description.abstract	Designing coordination compounds by ligand tailoring with therapeutic abilities has become a fascinating research field. In this work three new 1, 10-Phenanthroline and 2, 2’-Bipyridine mixed ligand complexes of ([Ni(phen)(H2O)4]Cl2, [Ni(phen)(bpy)(H2O)2]Cl2 and [Ni(phen)(bpy)(H2O)2](ClO4)2.11H2O) were synthesized. The complexes were characterized by using halide test, conductance measurement, and spectroscopic analyses (ICP-OES, FTIR, and UV/Vis) analysis and the result indicate that both ligands are coordinated to the nickel metal ion giving octahedral geometry for all complexes. Their in vitro antibacterial activities were also investigated on two Gram-positive Staphylococcus aureus (S. aureus) and Staphylococcus epedermis(S.dermis) and two Gram-negative Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae)) bacteria. However, all the complexes showed no activites againest all the pathogens. Keywords:-Ni (II) chloride, mixed-ligand complexes, 1, 10-phenanthroline, 2,2-bipyridine, antimicrobial activity	en_US
dc.language.iso	en_US	en_US
dc.subject	chemestry	en_US
dc.title	Synthesis and Assessment of Antibacterial Activities of a New Complexes of Ni (II) Containing 2, 2- Bipyridine, and 1,10-phenanthroline	en_US
dc.type	Thesis	en_US