Background: Cerebral palsy is the most common physical and motor disability in the globe, particularly in low income countries. Although the burden of the problem is higher in developing regions, especially in sub-Saharan Africa, it remains understudied in these areas. In Ethiopia, there is currently no adequate study that estimates the prevalence of cerebral palsy.This lack of data limits effective healthcare planning, resource allocation, and the development of targeted interventions to improve the quality of life for affected children and their families. Objective:To determine the proportion of cerebral palsy in children among neurologic cases having pediatric follow- up clinic and associated factors, Tibebe Ghion Specialized HospitalBahir Dar, North, Ethiopia, 2025 Methods:A hospital-based cross-sectional study was conductedamong pediatric patients diagnosed with cerebral palsy attending the pediatric referral follow-up clinic at Tibebe Ghion Specialized Hospital. The study period was encompassing case January1-30, 2026. Using a computer-generated simple random sampling technique, eligible patient records was selected. Data were abstracted using a structured Kobo data collection tool, then exported to Microsoft Excel and subsequently analyzed using SPSS version 27. Bivariable Logistic regression analysis was performed to identify factors associated with cerebral palsy. Variables with a p-value ≤ 0.25 in the bivariable analysis were included in the multivariable logistic regression model, and variables with a p-value < 0.05 were considered statistically significant. Results:Total of 324 children pediatric referral follow-up clinic neurologic patients were included in the study, of which 86of cerebral palsy, giving a proportionof 26.5 %( 95% CI: 21.7%–31.3%). Of these, 192 (59.3%) were males and 132 (40.7%) were females, yielding a male-to-female ratio of 1.46:1. After multivariable logistic regression analysis, Children whose mothers had no ANC follow-up (AOR = 2.20, 95% CI: 1.10–4.40, p = 0.026), Maternal antepartum hemorrhage (APH) (AOR = 6.87, 95% CI: 1.02–46.21, p = 0.047), children with CNS infection (AOR =6.872; 95% CI: 1.926–18.973) and perinatalasphyxia (AOR=10.898; 95% CI: 5.273-22.523) were independently associated with cerebral palsy. Conclusion:Lack of maternal antenatal care, maternal antepartum hemorrhage, and perinatal asphyxia and central nervous system infections found to be significant determinants for cerebral palsy. The findings emphasize the importance of strengthening antenatal care services, early identification and management of high-risk pregnancies, strict intrapartum monitoring, prevention and prompt treatment of perinatal asphyxia, and effective management of neonatal infections and infection prevention to reduce the burden of cerebral palsy.