This study the collection and exhibition management of Debrework Mariam Monastery Museum in Ethiopia, focusing on its establishment and growth, the museum collection, collection methods, object registration methods in the museum, heritage collection management and exhibition management. The research employs a qualitative case study design, utilizing primary data from interviews, personal observations, and photography, as well as secondary sources such as archival records and literature. The findings reveal that the monastery museum houses a rich collection of artifacts, including manuscripts, crosses, crowns, and religious relics, many of date back centuries and hold profound spiritual value. However, the museum faces challenges such as inadequate storage facilities, limited conservation resources, and insufficient documentation practices. Which threaten the long-term preservation of these artifacts. The exhibition management is also constrained by a lack of interpretive strategies and accessibility for diverse audiences. Despite these challenges, the monastery museum plays a critical role in preserving Ethiopian’s cultural heritage and engaging the local community. The study underscores the need for enhanced conservation efforts, professional training, and community involvement to ensure the sustainability of the museum’s collections and exhibitions. The researcher recommend, the Enarj Enawuga Cultural and Tourism Office should facilitate annual workshops for monastery custodians, led by professionals from the National Museum, covering core topics: object handling, museum management, display method, and basic documentation. Should be partners with an institution like Natural History Museum of Bahr Dar University, and IES to conduct a condition survey of the most vulnerable parchment manuscripts and provide targeted training in basic parchment care, focusing on handling.