Water is the prime natural resource, which is basic for healthful functioning of any ecosystem. However, estimating the groundwater quality potential zone has remained uncertain and less studied due to its complex nature. In the East Gojjam zone, the surroundings of Debre-Markos Town; in particular, groundwater development for various purposes is increasing. Therefore, assessment of the groundwater potential is very crucial for sustainable use of groundwater. Satellite images have been widely used for groundwater exploration because of its capability to identify indicators of groundwater potential zones. The main objective of this study it to delineate the groundwater potential of East Gojjam Zone, Amhara region, Ethiopia using geo information system combined with analytical hierarchal processes and water quality index methods. A purpose full sampling technique with a minimum of 50 sample size were collected from each category through observation and transact walkover. By consulting existing literatures, for this study ten most important groundwater controlling factors:- lithology, lineaments density, drainage density, geomorphology, rainfall, slope, land use land cover, elevation, and soil depth and soil texture that derived from satellite data and existing secondary data were selected. These thematic layers were prepared and converted to raster data format. Then, weightages were assigned for each thematic layers and ranked based on the knowledge that gained from literatures and expert opinions. Finally, the thematic layers overlaid to determine the groundwater potential based on the assigned rank and weight using Arc GIS spatial analysis tool. The groundwater potential map was validated through receiver operating characteristics (ROC) method of area under the curve (AUC) value were used based on wells yield data that are collected from different offices. The groundwater quality map was prepared based on the 52-groundwater point data of having quality test and yield results with geographic coordinates. The Ethiopian drinking water standard of 2013 using the WQI technique was used to test the groundwater quality. The results show that there are good agreements of 91.8% between the predicted groundwater potential map and the existing groundwater wells data. The groundwater quality potential map was reclassified into three groundwater quality potential zones of very high, high, and moderate. The result indicated that, about 92.09% (12,864.88 km2) of the study area was high, 6.24% (871.6 km2) of the study area was very high, and 1.67% (232.7728 km2) as moderate groundwater quality potential zone. The study suggested that, generated GWPZM would serve as useful guidelines for planners, engineers, and decision makers providing quick decision- making in the management of groundwater resources.