The change of LUCC due to human activities in the world has a notable impact on ecosystem services at regional and global levels, which are important for the survival of humans. North Mecha Woreda located in northwest Ethiopia is not escape from this phenomenon. This study assessed the impact of land use land cover change on ecosystem service values from the year 1994, 2004, 2014, and 2024.To achieve this objective explanatory sequential research design, and purposive and stratified random sampling technique was used. The result shows that land use/ land cover change result have significant transformation including a reduction in forest, shrub land, and grazing land while cultivated land, built-up area, bare land, and water body were increased. Specifically, forest land decreased by 54.18%, while water body increased by705.99%.The ecosystem service values were estimated based on benefit transfer method decreased from total $59.695 million in 1994 to $ 53.475 million in 2024 with a total change of $6.203 million. The result of ecosystem service value gain and loss indicates significant impact of land use land cover change. The coefficient of sensitivity (CS) in the study indicated that values were greater than 1 indicate that the quantification and estimation of ecosystem services in the study area was moderately elastic. The descriptive statistics indicated that strong agreement on land use land cover change causes ecosystem service value change in the study area. Generally; North Mecha Wored has experienced significant environmental changes, indicated by a decline in natural resources and loss of ecosystem service, showing the need for sustainable land management practice and forest reforestation and afforestation.