Drinking water sustainability is a critical issue in the World that results from a combination of limited water resource availability, lack of improper drinking water infrastructure, and/or increased drinking water demand. Behind this, there are no empirical findings of potential factors that were studied in rural parts of the study area. Therefore, this study focused on the assessment of factors affecting drinking water sustainability in Meket Woreda, North Wollo Zone. To realize the study findings; technical, social/environmental, financial, and institutional criteria of a suitable water supply system were analyzed and desk reviews were conducted. A household survey and key informant interviews (KII) were used to collect data. A household survey was conducted by administrating a structured questionnaire on randomly selected 156 sample respondent households and three KII was conducted with the Woreda water and energy office head and experts. The collected data were analyzed using both descriptive and inferential statistics. Form 14 water schemes evaluated by multi-criteria analysis (MCA), three schemes are sustainable, ten are partially sustainable and one is not sustainable at all. Sources yield inadequacy, depletion, unreliability, quality of water potability, potential contaminants availability, conflict of interest and the physical condition of the system as site, and technology inappropriateness, and natural threats occurrence are identified as major factors that have a significant impact on drinking water sustainability. In addition, improper water facility utilization and low/lack of caretaker/maintenance committee existence, functioning, linkage, and coordination with local government are identified as potential factors of drinking water sustainability. Assigning equipped professionals to design, and select sites and technology by ensuring the source yield and quality should be done at all phases of the project by providers with community engagement. Additionally, local government and other partners should create the linkage and continue coordination and capacity-building training with community-level institutions and community until the capacity of those institutions is strengthened. Key Words: Sustainability, Sustainability factor, Drinking water supply, Community participation