The purpose of this study was to investigate the effect of 8 weeks of plyometric training on neuromuscular fitness and skill performance of U-17 football trainees. To this end, the researcher used experimental design with 8-weeks of plyometric training program. The researcher used a comprehensive sampling method and all the 30 players in this age category were clustered as control and experimental groups by using a simple random sampling method. The samples of 30 football project players at Bahir Dar University with an age of (EG = 15.80± 0.77, CG = 15.87±0.83) formed the sample for the study. Only the experimental group received 40-60 minutes of plyometric training for 8 consecutive weeks with the frequency of 3 days per week. However, both groups engaged in the regular football training program that was given by the Academy. The selected neuromuscular fitness and football skills were (speed, vertical jump) and (shoot accuracy, pass accuracy) respectively. Field tests were taken as data-gathering instruments. To determine the difference between pre-training and post-training mean values, a paired-samples t-test was computed by using SPSS software version 23 at 95% significance level for both experimental and control groups. The results of the paired samples t-test for the experimental and control groups respectively were shoot accuracy test t (14) =-3.414 and t (14)=.076, pass accuracy test t (14)= -4.525 and t (14)=-.222 , 35 Meter sprinting speed Test indicate t (14)= 2.238 and t (14)= -.845 and vertical jump t (14)= -4.973 and t (14)= -.445. Generally, improvement is achieved in neuromuscular fitness and skill performance of the experimental groups. Thus, it is concluded that 8-weeks Plyometric training had a positive effect on the selected neuromuscular fitness variables and skill performance of the football players.