Synthesis, characterization, and assessment of antibacterial activities of copper (I) complexes containing ammonia and 2,2-bipyridine

mihiret, kassahun

dc.contributor.author	mihiret, kassahun
dc.date.accessioned	2024-11-13T09:58:06Z
dc.date.available	2024-11-13T09:58:06Z
dc.date.issued	2024-10
dc.identifier.uri	http://ir.bdu.edu.et/handle/123456789/16152
dc.description.abstract	Transition metal complexes are a promising class of compounds as antibacterial agents for inhibition of bacterial infectious diseases. This fact drives researchers to dedicate their time, energy, and resources towards the development of antibacterial agents with novel composition and modes of action. In line with this effort, in this study, a Cu+ complex, [NH Cu(bpy)]Cl was synthesized employing 2,2‘-bipyridine (bpy) and ammonia (NH 3 3 ) as ligands. The synthesis validity was confirmed through conductance measurements, and spectroscopic analyses (FTIR and UV/Vis), with the metal content determined via thermo gravimetric assessment. These analyses suggest a tetrahedral geometry for the synthesized complex. Subsequently, the in vitro antibacterial efficacy of these complexes was assessed against two Gram-positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis ) and two Gram-negative bacteria (Escherichia coli and Klebsiella pneumoniae), with their activities compared against commercially available tetracycline. The complexes exhibited significant activity against all tested pathogenic strains, demonstrating superior efficacy compared to the ligand and starting salt. Even though the activities of this complex were lower than that of the reference tetracycline, it can be considered as a potential antibiotic candidate, particularly against the tested bacterial strains passing the cytotoxicity investigation.	en_US
dc.language.iso	en_US	en_US
dc.subject	Chemistry	en_US
dc.title	Synthesis, characterization, and assessment of antibacterial activities of copper (I) complexes containing ammonia and 2,2-bipyridine	en_US
dc.type	Thesis	en_US