The purpose of this study was to investigate the effects of plyometric training on selected technical skills performance of grade 12 students’ at Mengesha Jemberie comprehensive secondary school ,Dangila, Ethiopia. The total subject for the study were forty (n =40) male grade twelve (12th) , who were selected via simple random sampling technique, students of mengesha Jembrie comprehensive secondary school in Dangila, Ethiopia 2023.. Through randomization students were assigned in to two groups, an experimental group (n=20) and a control group (n=20). The experimental group (EG) performed twelve-week low to moderate plyometric training, 3-days per week for a total of 60 minutes and the control group (CG) also performed twelve-week basic handball training 2 days per week for 60 minutes duration. The data was collected through field technical skill tests , viz., jump shoot test for jumping accuracy, accuracy throw test for passing accuracy and vertical jump test for explosive power. The data were analyzed via Paired sample t-test and Independent sample t-test by using SPSS version 23 with significance level of 0.05.Based on the analyzed data, the pre-posttest performance of EG were significantly improved in passing accuracy, shooting accuracy and vertical jump (p=0.001, p <0.05).similarly, the independent t-test shows the posttest performance of these variables in EG were significantly more improved than posttest result of CG (p=0.001, hence p<0.05). The results of this study shows that 12 weeks plyometric training improves shooting accuracy, passing accuracy and vertical jump explosiveness of grade 12th male students’ technical skills performance. Therefore the study recommend that coaches and sport science teachers should give concentration to plyometric training in their coaching and teaching handball practice.