Shape memory alloys for biomedical applications will be an essential resource for materials scientists and engineers working in the medical devices industry. Currently increasing the number of both replacement and revision surgeries for total knee joint replacements and Aseptic loosening, Excessive wear between articular surfaces and stress shielding of knee components are significant problems affecting the life of current total knee joints. In ordered to characterize the best shape memory alloy materials for knee implant components can reduce Aseptic loosening, Excessive wear between articular surfaces, stress shielding, the wear debris, improve the load transfer system, and provide anchorage between the bone and the component interfacing the bone. The characterization of shape memory alloy used in knee joint implants by studied mechanical properties of shape memory alloy and selecting those materials from CES Edu pack software. Study and characterize the fatigue life of shape memory alloys material with in knee implants and analysis and developed the desired threedimensional modeling of knee implants using radiant and ANSYS software from CT/ MRL data. The knee joint assembling components: tibia, femora and patella have better to produce from Co-Cr-Mo and tibia replacement components is better to produce from UHMWPE (ultra-high molecular weight polyethylene) when comparatively to other selected shape memory alloy materials with maximum fatigue life of 5.4702℮5 cycle. The maximum total deformation, maximum elastic strain and maximum Von- Misses stress of the selected material have 0.008876mm, 0.003279mm/mm and 53.376MPa respectively Keywords: knee joint .shape memory alloy, biomedical applications, shape memory effect, Mechanical characterization, and biocompatibility