Beressa is a major perennial river in the North Shoa Zone of Amhara regional state and it takes the northwest ward to join the Jema River, which form the tributary of the Blue Nile around a place known as Sundo Meskel near the lower side of Abay Bereha. The river uses for different purposes, such as, plantation, for drinking of cattle, cleaning and other similar purpose. Currently, the river faced the problem of pollution. The pollution of the river had a negative impact on the plantation, drinking and cleaning. This will in turn affects the right to a healthy environment as an independent right and as a corollary rights to other rights, such as the right to food, right to life, right to health and right to home and family. There is also school close to the river and the pollution of the river and the bad liquid materials affect children’s right to health and education. This research is a socio-legal type of research. The researcher employs both primary and secondary methods to gather data. The researcher used field observation, interview and focus group discussion with the concerned persons. The researcher also used other secondary sources like consultation of books, journals and other online sources. As per the findings of the research, the river is polluted. Its pollution has negatively affects the right to food of farmers around the river. The quality of water is not normal and it is not good for cultivation. The canal used for the purpose of plantation is filled by the dirty solid and liquid materials. As such the water is decreased. Moreover, the right to health of peoples living around the river is affected. The bad suffocation of the river had a negative impact on the breathing system, peoples using the river for cleaning purpose has got some disease. Since, there is school close to the research area; the pollution also affects children’s right to education and health. Even if the degree differs, the pollution happened by the fault of the government, the community and the industries around the river.