Access to safe drinking water plays an important role in human life related to health. The peoples of North Mecha district uses both improved and unimproved drinking water sources. This study was carried out to assess drinking water quality in terms of physicochemical and bacteriological parameters of the North Mecha district, Amhara region, Ethiopia. The study includes water quality analyses, sanitary inspection surveys, and socioeconomic assessments of the community. Drinking water samples were collected from 10/07/2022 to 04/09/2022 and from 23/01/2023 to 15/03/2023 during the rainy and dry seasons respectively. Samples were tested in both field and laboratory using the standard method of water examination and results were compared with WHO and Ethiopian standards. Statistical analysis was done using R version 4.3.0 software. The result shows that temperature, EC, total and calcium hardness, phosphate, sulfate, nitrate, and Ammonia values during both seasons were all within the WHO and Ethiopian drinking water standards. Whereas pH, turbidity, residual free chlorine, and iron were not within the standards in some areas. Statistical analysis shows that there was a significant difference between the medians of turbidity, ammonia, and nitrate across the two seasons. The bacteriological analysis result also shows that 48% (n=80) of the analyzed sample at the point of collection and 52 % (n= 208) of the analyzed sample at the point of use during the rainy season and 88% (n=60) of the analyzed sample at PC and 99 % (n= 180) of the analyzed sample at PU during dry season had detectable levels of E coli. The result also shows that there was a significant relationship between sanitary score and E coli result (p value= 0.00196) and the result shows that the risk of microbial contamination (E coli risk) decreases with the increase of household wealth quantile. Therefore, proper treatment of the water samples before consumption was recommended. Keywords: water quality, physiochemical, bacteriological, sanitary inspection, E col