Background. Re-laparotomy refers to operations performed within 60 days of an initial laparotomy. Magnitude of re-laparotomy is highly variable worldwide in various reported studies and highest was seen in gastrointestinal surgeries, while lowest in vascular surgeries. Re laparotomy is one of the causes of morbidity and mortality among patients with abdominal surgery. The costs, length of hospital stay and the psychological impact on patients and their families are high. Either globally or nationally the studies conducted about this problem are minimal. Evidences in Ethiopia shows that magnitude of re-laparotomy and its morbidity and mortality is increasing. In TibebeGion Specialized hospital, study was not conducted on this problem even if increasing number of re-laparotomy cases. Unless efforts are made to prevent it in advance by identifying its potential risk factors, it will continue as major public health problem of the country. Objectives: The aim of the study was to assess the magnitude and factors associated with re- laparotomy among adult laparotomy patients in TibebeGion specialized hospital. Methods: The study was conducted using a cross-sectional and monocentric study over a one-year period and included 389 adult patients who undergo laparotomy in TibebeGhion Specialized Hospital, Department of Surgery from September 2022 to August 2023 G.C. Patients with laparotomy cases were reviewed and analysed. Binary and multi variable logistic regression analysis was used to analyse the association between variables. The data wasentered and analysed using SPSS software version 25 and the results were described by using descriptive statics like summary value, tables of frequency, graphs and the associated factors for re-laparotomy were identified by using multiple binary logistic regression analysis with P value < 0.05 were considered statistically significant. Result: The magnitude of re laparotomy was 9 %, with 95 %( CI= 6.2-11.8) .In this study ,patients age above 60 years, (AOR = 16.36, 95% CI = [3.5-35]), P value = 0.002), duration of illness more than 120 hours , (AOR = 5.13, 95% CI= [1.35-22]) , pre-operative pulse rate more than 120 beats per minute, (AOR = 9.35, 95% CI= [3.06-19.43], dirty wound at index laparotomy, (AOR = 4.81, 95% CI = [1.23-10.05])were associated with re-laparotomy. Conclusion and recommendation; In TGSH, the magnitude of relaparotomy was high. Creating awareness on the community about the importance of early visit of health facilities when they feel illness will decrease the risk of relaparotomy. Key words: Re-laparotomy, site of pathology, peritonitis, wound dehiscence, Bahir Dar