Malaria is an acute febrile illness caused by plasmodium parasite and transmitted by the bite of the female anopheles mosquitoes. It has continued to be one of the major public health problems in Amhara regional state. The objective of this study was to determine malaria prevalence and associated risk factors among febrile patients who were attending at Kidist Hana Health Center, Fogera District, Amhara Regional State, Ethiopia, from December, 2022 to February, 2023G.C. In this cross-sectional study a total of 422 randomly selected individuals were participated in study Socio-demographic and clinical information of the study subjects was collected using questionnaire. Blood samples examined using Giemsa microscopy and Rapid Diagnostic Test (RDT). The data entered into, cleaned and analyzed using SPSS version 20. Association between malaria prevalence and socio-demographic characteristics and potential risk factors was tested with the chi-square and logistic regression. The differences were considered to be statistically significant if the value was less than 0.05. In present study, the microscopy results of blood smears indicated a positivity rate of 40.5%, while the RDT results indicated a positivity rate of 38.9%. By considering microscope diagnostic techniques as the standard since they are the most accurate diagnostic techniques for diagnosing malaria, the overall prevalence of malaria among feverish patients attending the sampled health center was 40.5%.Of these, Plasmodium falciparum and Plasmodium vivax, and mixed malaria infection accounted for 78.4%, 12.3% and 9.4% of the cases, respectively. The microscopy method was more sensitive (100%) than RDT although the RDT was more specific (100%) than microscopy (97.28%). In the current study area, age group less than 5 years (AOR =1.3: 95% CI=1.05, 1.64), marital status widowed group (AOR=4.46: 95%CI=1.19, 18.41), monthly income per household [AOR=1.39: 95%CI=1.05, 1.83) and number of ITNs per household (AOR= 7.2: 95% CI= 1.84, 28.86), were associated with malaria parasite infection. The findings demonstrated that malaria is still a significant public health issue in the study area. Thus, further efforts are required for monitoring and evaluating the effectiveness of control methods in order to completely eliminate malaria in the study area. Key word: Anopheles, Kidist Hana health center, Malaria, Plasmodium, Prevalence,