Introduction: Stroke is one of the commonest non communicable disease types that have a great public health impact both in developed and developing countries. However, in Ethiopia, the long term survival status of stroke patients was not well understood. Objective: This study was aimed to assess survival status and predictors of mortality among stroke patient at Felege hiwot comprehensive specialized hospital (FHCSH) from September 1, 2014 to August 31, 2019 Bahirdar, North West Ethiopia. Methods and materials: an institutional based retrospective cohort study was conducted among 368 registered stroke patients between September1, 2014 and August 31, 2019,and simple random sampling technique were used. Kaplan–Meier used to estimate survival rate with log rank test, to compare hazard of death covariate and both bi-variable and multivariable Cox regression analysis was conducted to identify predictors of mortality. Association was summarized using adjusted hazard ratio (AHR), and statistical significances were declared at 95% confidence interval (CI) and P-value < 0.05. Result: Of the368 stroke patients who were included in the analysis, 56 (15.2%) were died, and 312 (84.8%) were right censored. The overall survival rate was 72.2% at 51 months follow-up with median survival time of 0.26 months. Age greater than 65 (AHR= 6.31, 95% CI 1.75- 22.74), patients body temperature >37.1 degree centigrade (AHR = 7.14, 95% CI: 2.76-18.5), potassium level below <3.5 mmol/l (AHR =6.82, 95% CI: 1.9-23.53) and creatinine level >1.2 mg/dl (AHR = 7.85, 95% CI: 2.7-22.6), were the predictors of mortality. Conclusion and Recommendation age greater than 65 years, body temperature above 37.1degree centigrade, potassium level less than3.5 mmol/l, and Creatinine greater than1.2 mg/dl after admission. Therefore, interventions to reduce further mortality should focus in stroke patient. Key words: stroke, survival status, predictors, mortality, Ethiopia