Introduction: Whether the mother give birth her baby at home or in a health facility; in the majority of cases, postpartum care is not given adequately and are highly limited in Ethiopia in terms of coverage and schedule by which the service should be provided. Objective: The aim of the study was to assess prevalence and predictors of postpartum care uptake among mothers who gave birth in the last six months in Yilmana Densa District, Northwest Ethiopia. Method and Materials: Community based cross sectional study design was carried out by multistage sampling method with total sample size of 372 from April 1 to May 30, 2022. Structured interviewer administered pre-tested questionnaire was used to collect data. The collected data was entered into Epi data version 4.2 and then exported into SPSS window version 23. Bivariate and multivariate analysis were undertaken and information was presented by using simple frequency tables, graphs and pie charts. Result: The prevalence of postpartum care uptake was found 19 % (95% CI: 12.2, 20.8). Good knowledge about postpartum care (AOR=6.35, 95% CI: 3.41, 11.82), having four or more antenatal care (AOR=8.59, 95% CI: 4.56, 14.58), experiencing last delivery complication (AOR=4.89, 95% CI: 2.52, 9.49) and health information after delivery (AOR=3.57, 95% CI: 1.69, 7.53) were found to be statistically associated with postpartum care uptake. Conclusion and recommendations: Postpartum care had low uptake and it was identified inadequate by schedule in the district. Frequency of ANC visit, knowledge, postpartum complication and health information were associated factors for PPC uptake. This is an important message for the district health office, service providers and researchers. Key words: Postpartum, Postpartum care, postpartum care uptake, Yilmana Densa District