Urban poverty and unemployment have been increasing in several Ethiopian cities. Many people, particularly the urban women and other impoverished groups of society, were pushed into various income-generating activities in the informal sector as a result of these factors. Thus, the purpose of the study was to investigate the role of the informal sectors in improving FHH's food security in Sekota town. The study employed a mixed-methods approach. The quantitative data were collected using a structured questionnaire administered to 116 randomly selected women informal operators of the town and the qualitative data were gathered using FGD and key-informant interviews. Quantitative data were analyzed using univariate, bivariate, and multivariate techniques. Qualitative data were analyzed thematically. The study was guided by sustainable livelihood framework and self-assessment indicators of household food security situations were used to evaluate food security. Thefindings showed that the informal sector businesses haveimportant contributions towards enhancing the food security status of the FHHs. Of all sampled respondents 56% were food secured. The major factors that influence the household food security status of women informal sector operators were age, family size, income level, saving status, and experience in the business. The study found out that women informal operators in the study areas lack access to a variety of livelihood resources and opportunities, particularly credit, basic infrastructure, and workspace.The findings have implications to policy, social work intervention, and future research.