Background: Hazardous alcohol use is a significant public health concern and an important target for prevention efforts within both teachers and other populations. For such efforts to be maximally effective, comprehensive information regarding the prevalence and associated factors of hazardous alcohol use is necessary to initiate early interventions. However, there is a scarcity of research in Ethiopia, particularly among public high school teachers in Bahir Dar. Objective: To assess the prevalence of hazardous alcohol use and its associated factors among teachers working in public high schools at Bahir Dar City, Northwest Ethiopia 2022 Methods: An institutional-based cross-sectional study was conducted on public high school teachers in Bahir Dar city. 423 teachers were involved in study selected with simple random sampling technique from each high school by alphabetical order. Dependent variables were assessed using the Fast Alcohol Screening Test (FAST). Data were collected by Epicollect5 using a smart phone and exported to the SPSS statistical package version 25.0 for analysis. Bivariate and multivariable logistic regression analyses were conducted to identify associated factors with hazardous alcohol use. Adjusted odds ratios with 95% confidence intervals were used. A P-value < 0.05 considered significant. Results: a total of 407 teachers were involved with response rate of 96%.The prevalence of hazardous alcohol use was 65(16%) (95% CI: 12.40-19.54), 57(20.9%) were males and 8(6.1%) were females, and the prevalence of alcohol dependence was 1.7%. Male teachers (Adjusted OR 4.04 95%CI (1.66, 9.81) P <0.05), teachers 30 to 34 years old (Adjusted OR 3.41 95%CI 1.18, 9.91, P<0.05), first degree holders (Adjusted OR 3.66 95%CI 1.53, 8.76 p <0.05), psychological distress (K10≥22) (Adjusted OR 4.91 95%CI 2.44, 9.88, P0.05) and teachers with poor social support (Adjusted OR 3.95 95%CI 1.49, 10.45, P<0.05) were significantly associated with hazardous alcohol use. Conclusion: Evident level of hazardous alcohol use was detected in this study. There is an urgent need to address the seriousness of hazardous alcohol use among high school teachers considering highlighted associated factors and the important role of teachers they play in school-based hazardous alcohol use problem prevention strategies. Keyword: Hazardous alcohol use, high school teachers, high school, Ethiopia