BACKGROUND: Despite advances in non-invasive radiological techniques for the treatment of intussusception, management of the entity remains exclusively surgical in many developing countries, including Ethiopia. Ultrasound-guided hydrostatic reduction (USGHR) was recently introduced to the main referral hospital in Ethiopia and subsequently has been adopted as the initial management option for intussusception. Knowing the treatment outcome of hydrostatic reduction of intussusception and its associated factors will reduce the workload of hospitals and also help the Radiologists and the treating physicians to think of alternative treatments. OBJECTIVE: The objective of the study was to assess the treatment outcome of hydrostatic reduction and its associated factors among pediatric patients with the diagnosis of intussusception in Tibebe Ghion Referral Hospital, Bahir Dar, Ethiopia, 2022 GC. Methods: Institutional-based cross-sectional and a prospective study using systematic random sampling was conducted from Feb-August 2022 G.C on pediatric patients at Tibebe Ghion Referral Hospital, Bahir Dar Ethiopia. The sample size was 145 and all pediatric patients who underwent USGHR with US-confirmed intussusception who were clinically suspected of intussusception and sent to the Radiology department for ultrasound were selected. Data was entered using EpiData software and sent for analysis using SPSS version 26. Both simple and multiple binary logistic regression was employed to identify candidate variables for multiple binary logistic regression and factors associated with the treatment outcome of hydrostatic reduction. P-Values, of less than 0.05 were considered statistically significant. Result: From A total of 145 children who were diagnosed with intussusception, confirmed via ultrasound, 135patients (93.1%) had successful reduction following exclusion criteria. The mean age of children who were diagnosed with intussusception was 24.27 months. Among independent variables, length of intussusception and duration of illness were significantly associated with hydrostatic reduction outcomes. It was also found that the success rate increased in those patients with a shorter duration of symptoms and the length of the invaginated segment (P < 0.05). Conclusion: Ultrasound-guided hydrostatic reduction of intussusception is a simple and effective method for the treatment of Intussusception and can be performed with a high success rate. This study resulted in a success rate of 93.1%. The short duration of symptoms and length of the invaginated segment may have positive effects on the success of the procedure. Keywords: Intussusception. Pediatrics.Hydrostatic reduction.