Background:Although diffuse alveolar damage and respiratory failure are the key features of coronavirus disease 2019 (COVID-19), the involvement of other organs such as the kidney has also been reported. The reports of the prevalence of acute kidney injury (AKI) in COVID-19 patients vary widely. However, AKI among hospitalized patients with COVID- 19 in Ethiopia is not well studied. Objective: To determine the prevalence of AKI and its associated factors in hospitalized medical patients from February 2020 to March 2022 at TibebeGhionspecialized hospital, Bahir Dar. Methods: A cross sectional study design was used with a chart review for patients admitted to medical wards and all the necessary data was collected from hospitalized medical patients’ cards using the pre-developed data collection check list. Data was collected from December 2021 to April 2022. A total of 388patient charts were included in the study. A systematic random sampling method was used to identify the participants chart. The collected data was cleaned, coded and entered and analyzed using IBM SPSS statistics data editor version 27. Multivariable binary logistic regression analysis was conducted. P <0.05 will considered as statically significant. Results: The overall prevalence of AKI among COVID-19 patients was 25.1% (95% CI 21.1, 29.6).Those withMultiple co morbidity (AOR =4.036%, 95 CI : (1.089,19.739) ), Sever covid- 19 disease (AOR = 10.21% 95 CI : (1.027,101.644),above 4weeks symptom durations(AOR = 7.317%, 95 CI : (1.516 ,35.306), use cefepim(AOR=3.149%, 95%CI: (1.049,9.488), Lymphopenia(AOR=5.089%, 95% CI:(1.352,19.146), 1 – 2 weeks hospital stay (AOR=3.647%, 95% CI:((1.328,10.01)found to be associated significantly with increased risk for AKI. Conclusion:Acute kidney injury is a common feature in severely ill patients with COVID-19 pneumonia presenting with acute hypoxic respiratory failure. It is more common in patients with multiple comorbidity, long covid patients, those with lymphopenia as well as using cefepim. These data indicate that patients with COVID-19 should be monitored for the development of AKI while in hospital or after discharge and measures have to be taken to prevent this. Key words: Acute kidney injury, acute respiratory distress syndrome, Corona virus disease 19.