Background : acute kidney injury is defined as an increase in serum creatinine by 0.3 from base line within 48 hrs or by 50% from baseline within 1 week or urine output < 0.5ml/kg/hr for 6hrs.It complicates 5–7% of acute care hospital admissions and up to 30% of admissions to the intensive care unit. It is associated with a markedly increased risk of death in hospitalized individuals, particularly in those admitted to the ICU where in-hospital mortality rates may exceed 50%. Septic shock is defined as sepsis with hypotension in which vasoactive drugs are needed to maintain a mean arterial pressure of at least 65 mm Hg and a serum lactate concentration above 2 mmol/L despite resuscitation Methods: hospital based retrospective crossectional study was conducted from February 1/ 2022-october 30/2022 GC on patients admitted tibebeghion specialized hospital and felegehiwot referral hospital intensive care units in the past 5 years with a diagnosis of septic shock and age above 18 years to assess the prevalence of acute kidney injury in septic shock and associated factors with a calculated sample size of 161 .The study aimed to show the magnitude and associated factors to those working in the area so that the can take precautions to minimize the impact on patients. Result: a total of 161 patients were evaluated.50.3% were males. 44.1% of them were in the age group of 40-64 years. 131 (70.2%) developed AKI.37 (23%) had KIDGO stage 1 AKI; 37 (23%) had KIDGO stage 2 AKI; and another 37 patients had KIDGO stage 3 AKI. Age group 40-64 years [P value 0.047 (AOR of 2.747 95% CI of 1.016-7.427)] and use of adrenaline [P value of 0.045 (OR of 4.58 95% CI 1.00-20.35)] were significantly associated with developing acute kidney injury. Conclusion: In this study the prevalence of acute kidney injury is more than 70 % and the mortality was 58.4% with only 7 patients dialyzed and 1 patient having blood culture which calls for significant improvement in the management of patients with septic shock. Key words: septic shock, acute kidney injury, prevalence, associated factors tibebegion specialized hospital felegehiwot referral hospital