Background: Surgical site infection (SSI) refers to infections that take place within 30 days of an operative procedure and may extend to more than 30 days according to the surgical procedure. In Sub-Saharan Africa (including Ethiopia), there are few evidential studies regarding the magnitude of SSI and its associated factors. Therefore, this study was created to assess the incidence and predictors of surgical site infection among patients admitted to Tibebe Ghion Comprehensive Specialized Hospital, North West Ethiopia. Objective: To assess incidence and predictors of surgical site infection among patients admitted to Tibebe Ghion Comprehensive Specialized Hospital, Bahir Dar, North West Ethiopia. Methods: Prospective observational study in all patients that undergone major surgical procedure at surgical ward of TGCSH, Bahir Dar, Northwest Ethiopia, from March 1/2021 to- May 30/2021 E.C. A consecutive sampling technique used in which every subject meeting the criteria of inclusion is selected. The estimated sample size is 173. A structured research tool will be used to collect all necessary data from the patients and patients’ medical record. The collected data will be entered into EPI data version 3.1 software, then will be exported to SPSS version 25 for analysis. Result: Out of 173 patients, 41(23.7%) patients developed SSIs. Among patients who developed SSIs, 33(80.5%) are superficial SSI. Conclusion: The incidence of surgical site infection in study setting was 23.7%. The occurrence of surgical site infection was associated with age greater than 40, emergency procedure and presence of previous hospitalization. Key words: Surgical site infection, Incidence, risk factors, outcomes, Ethiopia