As the workplace is where 60% of the world people spent one-third of their time, that they need it to be safe and healthy from any kind of hazards. Work-related occupational health hazards can cause physical or psychological harm or disease to workers. Textile industry, labor-intensive at the same time the hazardous industry, has generally strong Occupational Safety and Health (OSH) concerns. Therefore, this descriptive-analytical study aims to assess and evaluate the risks and practices towards OSH at Bahir Dar Textile Share Company (BDTSC) and identify hazards, their driving factors and possible solutions to prevent and/or mitigate those hazards. Consequently, DIARBENN method, French's workers’ activity based approach was employed. Further primary data were collected through the European Occupational Safety and Health Agency (EU-OSHA) checklist based observation, direct measurements of workplace conditions such as sound and noise level, lighting conditions, dust particles concentration, and pretested questionnaire from the extensive literature review; Hence, in this study 260 questionnaires distributed for the three main departments, spinning, weaving and finishing/garment. Those collected data analyzed using risk matrix of DIARBENN method and descriptive statistical analysis like frequency and crosstab analysis, correlation analysis, and linear regressions. As a result 20 major hazards have been identified throughout the company. Furthermore, the criticality levels of these identified hazards have been assessed through two criticality levels (i.e. first or row criticality; and second or residual criticality). Among those assessed hazards slips, trips and falls, cuts and lacerations, walking on sharp objects, being hit by falling objects and crashes and collisions were identified to be the most critical accidents, while cotton dust inhalations and loud noise/Tinnitus were the most prevalent/critical chronic hazards in all three departments (i.e. spinning, weaving and finishing/garment ) with different magnitudes. Finally, since workers are affected by more than one of the identified hazards, a comprehensive risk management method has been developed. This method helps to manage the risks easily and in a well-organized way. Also enhance effectiveness through workers activity based approach. Generally, this study creates a new insight and full-picture about safety and health in the textile industry, covering all production departments. Keywords: OSH, risk management, textile industry, textile hazards, risk assessment, work-related accidents and chronic diseases, Ethiopian textile industry