Soil transmitted helminthes (STHs) are parasitic worms that infect humans and spread via oval or larvae-contaminated soil. In order to become infectious, some parasites' immature or undeveloped life-cycle stages (eggs) must first develop or incubate in the soil for a certain amount of time. Round worms (Ascaris lumbricoides), whipworms (Trichuris trichiura), and hookworms (Nectar Americans and Ancylostoma duodenale) are the most prevalent and well known of these parasites. Due to their shared diagnostic requirements and therapeutic responses, many STH species are typically treated collectively. The objective of this study was to determinethe prevalence of soil transmitted helminthic infections among school children in Liwaye Town, South Gondar zone, northwestern Ethiopia.A cross-sectional study aimed at determining the prevalence of soil transmitted helminth infections among schoolchildren was conducted between January 2022 to May 2022. Structured questionnaire was prepared on socio demographic, economic and recognized risk factors of STH infections and administered to sample children chosen using systematic random sampling in their mother tongues. Stool samples collected were examined with formal ether sedimentation technique to detect STHs positivity. Data were entered into and analyzed using SPSS version 26.The overall prevalence of STH infection was 18.7%, , Ascaris lumbricoides45(11.7%)was the most dominant followed by Hookworm18 (4.7%), and Trichuris trichiura9 (2.3%). In this study failure to wash after defecation(AOR=3.67(95%CI:1.23-10.89)),practiceofnot trimming fingernails(AOR=15.43(95% CI4.37-54.42)), shoe wearing habit (AOR=5.78(95% CI2.52-13.25)), and unavailability of latrine (AOR=5.79(95% CI2.33-14.40)) were identified as predisposing factor for STHs infections. However, characteristics like sex, grade, age, types of latrine , education level, washing hand practice before meal and contact with the river water were not substantially linked to STH infections. School based deworming for STHs, provision of latrines and awareness creation toward personal hygiene and modes of STH infections are necessary.