Intestinal parasitic infections are major health problems in many developing countries, particularly among pre-school and school-aged children. The current study aimed to determine the prevalence and associated risk factors of intestinal parasitic infections among primary and junior school students in Atsedemariyam town. A cross-sectional school-based study was conducted from February to june, 2022. A total of 403 school students were involved in the study, and study subjects were selected by stratified random sampling techniques with lottery method. A structured questionnaire and direct observation were used to obtain relevant information on risk factors associated with intestinal parasitic infections, and stool specimens were collected and examined using wet mount and sedimentation techniques. Chi-square and logistic regression analysis were used to assess the possible association between dependent and independent variables. The overall prevalence of intestinal parasites in the current study was 35.7%, and eight species of intestinal parasites were identified. Entamoeba histolytica/dispar was the predominant species at 10.4% (42/403), followed by Ascaris lumbricoides 8.4% (34/403), hookworm 7.2% (29/403), Giardia lamblia 6.2% (25/403), Taenia spp 2.7% (11/403), Trichuris trichiuria 2.7%(11/403), where as Schistosoma mansoni 1.24% (5/403), and Enterobius vermicularis 0.5% (2/403) were rare or minor case. In this study, The result of multivariate analysis revealed that the odds of being infected with intestinal parasites were high among student whose age categories were 7-10 years (AOR=26.8, 95%CI=1.8-408.8,P=0.018) compared to whose age greater than 16 years. Students who did not cleaning and cutting your finger nails (AOR =8.6 , 95% CI =1.8-41.4 ,P=0.007) compared to good finger nail hygiene were strong predictors of intestinal parasitic infections among primary and junior school students. Therefore, all concerned bodies should design practical action plans for effective prevention and control of IPIs in the study area. In general creating awareness on IPIs among school children and their parents in particular should be needed