The purpose of this study was to evaluate the effect of circuit training and interval training on selected physical fitness and physiological variables of Addis Raey secondary and preparatory school male football players. A true experimental research design was employed. To achieve the purpose of the study 63 participants were selected randomly. The age of the participant range from 15-18 years. The participants were also grouped into circuit group (n=21), interval group (n=21), and control group (n=21) randomly. The experimental groups engaged in training for three days a week but the control group did not perform special training. The selected physical fitness and physiological variables were muscular endurance, speed, flexibility, agility, resting heart rate, blood pressure, and respiratory rate tested in the study before and after the treatment. SPSS software (version 20) was used for analysis. Mean, SD, two-way ANOVA, and LSD post hoc tests were employed to analyze the collected data. The significant level of p ≤ 0.05 compare to the post-test result means the difference between the groups. The result indicated after three months circuit training and interval training had significantly improved the selected physical fitness and physiological variables. But when the researcher compare the mean difference between each selected physical fitness and physiological variables circuit training showed better improvement. The result concluded that both circuit & interval training methods showed better improvement than the control group on the selected physical fitness and physiological variables due to 12 weeks training program. The coach considers circuit and interval training exercises in their training program, it helps the trainees to improve their muscular endurance, speed, flexibility, agility, resting heart rate, blood pressure, and respiratory rate performance.