Honey is nutritious food collected from various flowering plants by honeybees. It contains mostly carbohydrates, water, trace volatile compounds and other compounds. The objective of this study was Profiling of Volatile Compounds in Honey of Selected Zones of Amhara Region specifically East Gojjam, West Gojjam, South Gonder, North Wollo, and Awi. 2.5 g from each seventeen collected samples was taken and extracted with 12.5 ml of dichloromethane using Solvent Extraction. Then the supernatant was taken and treated with sodium sulphate to remove the water molecule from dichlomethane extract using Solvent Extraction. Finally the water free dichlomethane extract was filliterd using Acrodisc syringe filter and submitted to GC-MS anlaysis. The result indicates the presence of 42 volatile compounds in the studied honey samples. Among these compounds, some of them were hydrocarbons (13), Alcohol (8), acids (5), aldehydes (5), ketones (3), Amides (2), Ester (2), Amin (1), ether (1) and others (Disulfide, di tert-dodecyl and Paromomycin). The most abundance volatile compound was Hexadecane (62.9%), while which is found in sample from South Gonder zone, while the least abundance compound was 9-Octadecenamide (0.08%). This implies that Amhara regions honey are rich in diversified volatile compounds.