Adaptive leadership practices and its relationship with organizational learning and organizational effectiveness, as well as the prediction of the variables in Ethiopia's Amhara National Regional State public higher education institutions are investigated in this study. The purpose of the study is to examine the practices of adaptive leadership, the current status of organizational learning and organizational effectiveness and the relationship between adaptive leadership and organizational learning and effectiveness of the institutions. The study used mixed method research design. The target population of is made up of three groups: 18 presidents, 440 middlelevel officials, and 5239 academic employees. The sample size was determined to be 630 (ten presidents, 220 middle-level officials, and 400 employees). A questionnaire containing multiitem scales adapted from previously produced models, as well as semi structured interview items, were used to collect primary data. The quantitative data was analyzed using percentages, mean values, one-sample t-test, correlation, and regression analysis while qualitative data was analyzed using thematic analysis. Because of the current uncertain and dynamic challenges that institutions face, the findings demonstrated that leaders practice adaptive leadership at all levels. This reveals that as a result of the leadership practices, organizational learning has been observed in the institutions. In addition, the result indicates that adaptive leadership implemented by leaders facilitated the augmentation of organizational effectiveness in HEIs. The findings also show that the variables have a significant and positive relationship. This implies that the more adaptive leadership is implemented in the institutions, the higher the learning capacity at the individual, group, and organizational levels will be. Additionally, the results show that the practices of adaptive leadership have significant predictive power on organizational learning and effectiveness. Hence, HEI leadership at all levels must understand that adaptive leadership is the solution to the current unforeseen problems and adopt ways to encourage OL in order to fulfill the goals set forth by their institutions.