The major objective of this thesis is to investigate and reconstruct the history of epidemics in the Awrajja of Lasta between the 1940s and 1991. The focus of this thesis is on the pathogenic factors and implications of the outbreaks in the study area and measures have been taken by the community of Lasta, governmental, and non-government organizations to reduce the devastation of epidemics. The majority of the sources I used in this research were archival; Books, articles, journals, government records, reports, and other published and unpublished sources of knowledge about the subject were also used. Furthermore, I was able to collect material from oral sources during interviews with numerous Lasta communities to demonstrate the historical consequences of my study. Environmental change became the cause of the outbreaks of epidemics during the period from the 1940s up to 1991. Typhus, malaria, smallpox, cholera, meningitis, and measles, including crop pests, rabies, and cattle diseases were dangerous diseases at least negatively affected the residents of several people in the study area. The above diseases were aggravated by the consecutive famines from the 1960s to 1980s. The finding of this study shows that the majority of the epidemics in the population of Lasta Awrajja were communicable diseases. The high prevalence of epidemics factors had lack of sanitation, malnutrition, overcrowded, inadequacy, and unavailability of public health services. The problem was aggravated during drought, and famine times, migration, interruption of the health service due to war and conflict, and lack of infrastructure. The paper has attempted to identify the major epidemics, the impact of epidemics, and the role of the government and nongovernment to prevent epidemics in Lasta to give a general picture of the historical development of different diseases shown in periods.