Introduction Uterine rupture is non-surgical tearing of all layers of pregnant uterus after fetal viability till delivery. Maternal morbidity and mortality has been one of the most challenging health problems that concern the globe over the years,especially in sub-Saharan Africa. Uterine rupture is one of the peripartum complications which cause nearly about one out of thirteen maternal death and the remaining survivors encounter immediate and long-term complications. Uterine rupture is more prevalent in developing countries including Ethiopia. Uterine rupture was one of a single commonest cause of maternal mortality accounts (33.2%) with the case fatality rate of 11%. The overall prevalence of uterine rupture in the study area was found to be 7.2%. Despite uterine rupture is one of the deadly direct causes of maternal mortality, there is no adequate study done in the study area. Objective: The objective of the study was to assess the proportion of ruptured uterus and its associated factors at Debre Tabor referral Hospital. Methods: A cross-sectional study design and was conducted in Debre Tabor Referral Hospital. Cases of ruptured uterus from the total deliveries with in the 5year period were included and without replacement simple random sampling technique was used to select them. Patient cards, major operation registration log books and labor ward registration log books were used for data collection. Data was collected through semi-structured questioner. Each filled questioner was checked for completeness and coded, and then it was entered into Epi Info version 7.4.2. Finally, data was cleaned and exported into statical package for social science version 21 for further analysis. Bivariable and multiple variable logistic regression were employed to determine associated variables. At 95% confidence interval, P-value less than 0.05 was used to decide the significant of the association with the independent and outcome variable. Result:According to this study the proportion of uterine rupture in the study area was found to be 7.2%, i.e. from 363 chars reviewed 26 had ruptured uterus. Conclusion: uterine rupture is the most devastating public health problem, which affects all pregnant women especially those living in less developed countries like Ethiopia. according to my study, CPD, non-use of partograph, use of misoprostol and oxytocin for induction/augmentation of labor, duration of labor> 24 hours were found to be variables with strong association with uterine rupture. Key words: Proportion, Uterine Rupture, Associated Factor, Debre Tabor, Referral hospital, Ethiopia