Introduction Gallstone is the formation of stone in the gall bladder lumen. Gallstone is one of the most common digestive surgical disorders worldwide. More than 95% of biliary tract affections are due to gallstone disease. Among biliary tract diseases, cholelithiasis is the leading cause of inpatient admissions for gastrointestinal problems. A primary symptom of gallstones is repeated attacks of pain, often referred to as biliary colic. The management of patients with symptomatic cholelithiasis or for those patients who develop complications from gall bladder stone is surgery. Globally around 90% of cholecystectomy is done laparoscopically Objective: The purpose of study was to assess the different means of cholecystectomy and its short-term surgical outcomes of cholecystectomies done in Tibebe Ghion Specialized Hospital in two years period 2019-2020. Method: The study was cross sectional retrospective chart review study. Patients with gall stone disease and operated in the study period was included in the study and no sampling technique is used. Data will be was analyzed with SPSS version 20 and finally presented in table, graphs, charts and words. Result: A total of 173 open and laparoscopic cholecystectomies were done in the two years period in Tibebe Ghion Specialized Hospital. One hundred thirty-two (76.3%) of patients were females and the male to female sex ratio was 1:3.2. The age distribution of studied patients ranges from 19 to 78 years and the mean age of patients were 41.82 years. The average post-operative hospital stay of patients was 3.85 days and patients who do have admitted in emergency condition do have extended average post-operative course (7 days). Post-operative hospital stays also affected by presence of post-operative complications average stay is 8 days. Of all patients who have under gone cholecystectomy 20 (11.6%) develop different types of complications. Surgical site infection was the commonest complication encountered accounting 15 (71%). Conclusion: Females are most frequently affected by cholelithiasis than males. Open cholecystectomy still is responsible for the major operative procedure conducted in gall stone patients but laparoscopic cholecystectomy is still the significant contribution of surgery. Twenty-five of patients with cholelithiasis do have additional medical illness as comorbid condition and hypertension is the commonest medical comorbid illness encountered. The major surgical complication rates were higher in laparoscopic cholecystectomy group as compared to open cholecystectomy group which is. Surgical site infection was the commonest surgical complication encountered.