Introduction:. Anemia is a common hematological problem in the neonatal admissions ranging from 23-66% in sub-Saharan Africa .Unless detected and treated properly ,it adversely affects the growing infant. Data about the magnitude and contributing factors of anemia in sick newborns are lacking in Ethiopia, so knowing the magnitude and contributing factors may reduce the long term, untreated complications of anemia. Objective: The overall aim of this study was to determine the prevalence and associated factors of anemia among those newborns admitted toTibebe Ghion specialized hospital. Methods: Hospital based cross sectional study was conducted among 272 newborns admitted to Tibebe Ghion specialized hospital from February 1 to May 30, 2021GC. Pretested and structured questionnaire containing socio demographic, clinical and laboratory parameters was used for data collection. Data were collected by trained nurses and residents after obtaining ethical clearance. The data were entered through Epi-data version 4.6 and analyzed using SPSS version 23.0 computer software. Descriptive statistics were performed using frequency, mean and standard deviation. Bivariable and multivariable binary logistic regression were done to identify risk factors of anemia.Adjusted odds ratio with 95% confidence interval at a p-value<0.05was declared as statistically significant. Result: About two third 177 (65.1%) of the new born babies were male and 152 (55.9%) of the newborn had a birth weight of ≥ 2500 gram. The most commonly diagnosed medical condition were sepsis 218 (80.1%) and prematurity of birth 78 (28.7%).The prevalence of anemia among newborns in this study was 63 (23.2%) [19.1%- 28.7%].Newborns with a gestational age of 33-36 weeks was 64%[0.36(0.17-0.96)] less anemic as compared to those having gestational age of ≤ 32 weeks . Conclusion:The prevalence of anemia among newborns in Tibebe Ghion specialized hospital showed high. Gestational age was significantly associated with newborn anemia. So, it is better to properly educate and advice maternal women’s about newborn anemia during antenatal care follow-up. Key words: Newborns, Anemia, Associated factors,Bahir Dar