Background: Communication is the exchanging of information from one group to the other through mutually understood ways. Communication barrier is anything that prevents receiving and understanding the messages. poor communication between patients and the nurses’ result in an increased hospital stay and patient dissatisfaction. This study will provide basic information on the level of nurses to patients’ communication and perceived barriers in government hospitals of Bahir Dar city. Objective: To assess the level of the nurse to patient communication and perceived barriers in government hospital of Bahir Dar city, Ethiopia, 2020 Methods: Institution based cross-sectional mixed-methods study was conducted from February 24 to March 9/2020 in government hospitals of Bahir Dar city. The totals of 380 nurses were included in the quantitative study by using simple random sampling. Data were entered into Epi Data 4.6 and analyzed with a statistical package of social sciences version 25. Data were mainly analyzed using descriptive statistics, and binary logistic regression. For the qualitative study, purposive sampling technique was employed, and seven participants were interviewed. Thematic analysis was used. Results: From the total participants 36.5% of nurses were found to have poor communication. Variables that have statistically significant associations with the level of communication were educational level (P<0.001), work experience (P<0.001), the unwillingness of nurses (P=0.019), and lack of communication skill (P=0.012). The highest perceived communication barriers were lack of continuous training with 82.7% followed by workload with 80.8% and the lack of medical facilities with 79.2% as reported by nurses. All environmental-related barriers were the perceived barriers of the nurse to patient communication. Conclusion and recommendations: In this study, the communication of nurses to patients is found to be low. Nurse professionals need to have adequate or good communication skills to solve or overcome the problem of patients. To enhance communication with the patients; nurses and other stakeholders like the ministry of health, the health bureaus, and hospital authorities need to recognize the communication barriers. Keywords: communication barrier, nurse-patient, Bahir Dar, Ethiopia, 2020.