Background: Antimicrobial resistance is becoming a serious health problem worldwide. Gram negative bacilli are emerged as resistant for carbapenem and this becomes worst,if they produce carbapenemase. Additionally, the magnitude of extended spectrum beta-lactamase production among them is also widely distributed in the globe. However, specific data on the extent of carbapenem resistance and beta-lactamase production around the study Felege-Hiwot Referral Hospitalis scares.