Ethiopia is one of the countries in the world where armed struggle and terrorist attack is potentially high. Unfortunately, however, researches on blast protection of vehicle structures in the security forces are virtually absent. This paper aims to numerically investigate the response of sandwich panel with functionally graded core for blast protection of vehicles (Ural4320) structure with similar geometrical parameters for displacement and acceleration. Corecell TM A-series styrene acrylonitrile (SAN) foam (A400, A600, and A800) were used. The foam variants were placed inan increasing and decreasing density. The core was wrapped with Rolled Homogeneous Armor (RHA)to produce the sandwich panels. The numerical model and analysis was done using the Explicit Finite Element (FE) simulation software package (ANSYS/Autodyn 2020R2). Analytical blast pressure load for 10kg trinitrotoluene (TNT) was calculated and aone-dimensional Euler wedge mesh in axisymmetric conditions was used to select 2mm mesh size by comparing the closeness in value to the Kinney and Graham model. The response of the panels was recorded at four critical points (two at the front and two at the back of the panel). The study revealed that both displacement and acceleration significantly decrease location wise as it moves from the front face to back face and the core arrangement of plates has impacted the magnitude of displacement and acceleration. Soft to hard arrangement of coreshavea better impact in reducing acceleration as well as displacement. As a result, constructing a floor panel with graded sandwich core panels can help to offset the high degree of blast-induced loads. Keyword: TNT, Sandwichpanel, Functionally Graded Material, Finite Element Analysis, Acceleration, Displacement