BACK GROUND: Acute poisoning is a common reason for emergency department visit and hospitalization worldwide. The unrestricted distribution and easy access to insecticides and rodenticides with possible public health hazard contributes a lot in worse outcomes. It is important to know the outcome and associated factors of acute poisoning cases in particular area in order to take appropriate planning, prevention and management techniques. Till date, no study on acute Poisoning is done in FHCSH and its catchment area. This study assessed outcome and associated factors of acute adult poisoning cases in Felege Hiwot Comprehensive Specialized Hospital for two consecutive years