Background: Spleen is the largest lymphoid solid organ containing reticuloendothelial system and located intraperitoneally in the left upper quadrant of the abdomen. Knowledge of the normal range of spleen size in the population being examined is a prerequisite. Established normal limits of spleen dimensions remain few in the Ethiopian population, and the ultrasound data from the previous studies of different countries demonstrated that racial and geographic differences could affect the splenic dimensions; this necessitates the determination of normative data of spleen dimensions for our population. Ultrasonography is the best imaging method to assess the spleen and splenic size.