Unscientific and unsuitable solid waste disposal selection can have numerous detrimental impacts on the local environment and public health, and encounter criticism from the political opponents and the local community. This study aimed at selecting a suitable solid waste disposal site for Dessie town by utilizing an integrated geographic information system (GIS) and multi-criteria evaluation (MCE). To achieve the target of the study, the first step was determining the capacity of the required site by estimating solid waste generation rate and then overlay suitability analysis of different layers were done. To calculate the rate of waste generation, amount of generated wastes collected from a total of 146 households and 59 none households for seven consecutive date on April 2019. For selecting waste collection households and none households’ multi-stage sampling techniques were employed. For site suitability analysis, twelve relevant criteria were employed. Analytic hierarchy process (AHP) was used to weight and standardized each criterion. The result shows that average daily waste generation rates were 0.45 kg / person / day for household and the total none household waste were estimated at 40.28 ton/day. From suitability area analysis, 12.03% of Dessie town, was suitable for landfill which satisfies the size of 1.49 km 2 for total MSW generated and 0.43 km 2 for non-recyclable solid waste. Finally, Landfill site (LF- 1) were the first option from the candidate site which delineated from these suitable classes based on the size of the site, wind direction and to the center of the town using the comparison of weight of criteria in AHP evaluation. The suitable site is found at the northern direction of the town namely Borumeda to the road of Kutaber town. However, detailed hydrogeological surveys should be carried out to further evaluation and the geotechnical types of defensive design measures shall provide for the selected landfill sites such as compacted clay liner, geomembrane and geotextile filtration since the geological formation of the site has less degree of weathered and fractured. The result of this study will help as a preliminary input for further studies and the information supports for the concerned authorities to improve solid waste management of Dessie town. Key words; Analytic Hierarchy Process, Dessie town, GIS, Landfill Site